TLDR:PROS: This may be a bit premature, but success in controlling my blood sugar 5.5 times out of 6 times leaves me feeling very excited about discovering this supplement. Just started using this supplement 5/21/17, and it has worked amazingly well so far - my BS appears to be controlled, and I'm no longer feeling groggy and sleepy after eating (except after a meal with tofu).I also found this supplement very easy to take, easy on my stomach, with no untoward effects - doesn't taste great, and even though it's in capsules you can't help but taste it, but that's about it.CONS: The only problems so far is that the ingredient lists on the bottle I received is different than the pictures indicate - it is missing the Pepsin - see images and compare. Evidently there was a change in formulation. which makes this product identical to another product that sells for less: True Health Ultimate Lectin Defense True Health Ultimate Lectin Defense - Natural Defense For Food Intolerance - 120 CapsulesThis product really works, and generally works well. I would expect the Ultimate Lectin Defense to work equally well since it i the exact same formulation as what I actually received. The only reason I chose to pay more for this one is because I expected it to have the Pepsin as an additional ingredient. - My expectations weren't met - see update just below:UPDATE:I decided to try an identical product with the pepsin still in it - BIG MISTAKE! Pepsin is the cause of a particularly bad form of reflux known as Silent Reflux which is difficult to diagnose because it mimics other issues like sinusitis. I started suffering symptoms of this within a few days. I have since tried the True Health version linked above, and it doesn't seem to be doing as good of a job as Lectin Lock, so it's back to Lectin Lock for me!BACK TO ORIGINAL REVIEW:Also it seems that this formulation isn't as effective against soy lectins. Today my blood sugar went up into the 160's at 1 hour with considerably groggines after eating a noodle, veg and tofu dish. The 2 hour blood sugar was in the normal range, but the grogginess continued for most of the day, even after my BS was down in the 80's. Evidently the tofu was not fermented, and Lectin Lock doesn't appear to be entirely successful against soy lectinsSo for my indepth review: Just a heads up, this is lengthy.Some background info for those who aren't very familiar as to why one should be avoiding dangerous lectins, or why lectins are even a big issue - I recommend getting a copy of the book "The Plant Paradox" and giving it a serious read. The author is a practicing Cardiologist, heart surgeon, heart transplant surgeon, with expertise in immunology and a pioneer of "Xenotransplantation" - which is the transplanting of plant materials into animals (the most recent news article I've come across was in the last couple of months where a spinach leaf was transformed into living, beating heart tissue). His published research and articles number over 100 with at least 20 or more in Xenotransplantation alone. While not the first one to note a connection between certain health issues and lectins, his background, knowledge expertise, along with extensive data from 10's of thousands of patients, provided the opportunity to connect the dots between lectins from the "grazer's" foods - grasses/grains/legumes, as well as other disruptors, to the rise in the plethora of health conditions we've been seeing despite the "healthy" diets being promoted. Turns out these "healthy" diets are the problem, not the cure. By removing these lectins from his patient's diets, he's seen a multitude of health conditions, even incurable ones, disappear. He is well qualified to speak on such a topic. Not only does he describe what is wrong, but he also tells us how to fix it, even giving us food lists and recipes and meal plans. This is a good place to start.Needless to say, I've become very aware of the need to change my diet and remove these offending lectins, which means removing the foods that contain them: wheat, corn, soy, legumes, nightshade foods and products formulated with them. Corn and wheat are 2 very big biggies with soy following right behind, especially since corn is in almost everything now. And this is just the beginning. This doesn't even begin to address the extra lectins in GMO foods, the exposure to chemicals, antibioitics, etc in our food, our environment, and the drugs we take which wreck havoc on the microbiome in our guts - our "2nd Brain." This constant assault on our microbiome makes it easier than ever before for these lectins to get past our defenses and into our bodies. Because corn and wheat, and even soy, are so pervasively found in our foods today, removing them from our diet requires a dramatic change in what we eat, and even in how we prepare and cook some of them. This is no easy task, especially if one eats mostly prepared foods or eats out.Ideally we should just make the necessary changes to our diets right away - cut out the old, bring in the new and be done with it. However, the reality is, this can be very hard for some of us to make such a drastic change overnight. We need time to get our ducks in a row, prepare ourselves and our homes for a new way of eating and living so that the change can be successful and permanent. However, we don't want to delay experiencing the benefits, we want to be impacted less by these dangerous lectins now. What do we in the meantime?That's where I believe supplements like this can be very helpful.One of the common supplements many use today to relieve joint pain is glucosamine - specifically N-Acetyl Glucosamine. How glucosamine works is very interesting. Some lectins mimic proteins found in cartilage. When these lectins do get into the body, due to their similarities to a protein in cartilage, they confuse the body's immune system into attacking itself as well as the lectin(s), thus resulting in autoimmune disease. The reason glucosamine works is because it blocks these lectins by keeping them in the digestive tract so they don't invade the body and lodge in one's joints. I decided that taking glucosamine now along with making some food changes might be a good compromise while I set everything in order (which includes convincing my family to eat a different diet).That's when I came across this supplement, which not only has the N-Acetyl Glucosamine, but several other substances known to help keep lectins in the digestive tract where they belong, such as okra.I decided to give this a try. And I had a question: What do blood sugar levels and feeling groggy after eating have to do with lectins?I wondered how this would affect my blood glucose. That might sound strange at first glance, until one realizes that one of the most dangerous lectins is WGA - Wheat Germ Agglutinin (one of many agglutinins - not a gluten) - which actually impacts our body's ability to utilize glucose and insulin. It is one of the smallest lectins and can get past the lining of the gut much, much more easily than other lectins; and not only that, it can also cross the blood brain barrier. Since one of the ways lectins work is by mimicking hormones to confuse and disrupt intercellular communication, this one is especially pernicious as it can mimic insulin. This means it can bind to insulin receptor sites on cell walls, send its bad instructions to the cells - for instance to store fat - thus interfering with glucose metabolism on one hand (starving cells of glucose) and turning it into fat on the other (making us store more fat), and keep insulin from effectively doing what it's supposed to do. While WGA is at work doing its thing, insulin's ability to communicate its instructions to the affected cells is disrupted.WGA is found in the BRAN of wheat (think whole wheat bread) and rice (think brown rice). So if I'm going to eat bread, then to avoid WGA, I'm better off eating white bread - and sourdough is better yet as fermentation can reduce lectins; and if I'm going to eat rice, to avoid WGA, I'm better off eating white rice. Completely opposite of what we've been taught is good and bad for us.We've heard a lot of talk about glycemic index of foods, with white bread being worse than whole wheat bread, because it turns into sugar in our bodies faster, raising our blood glucose faster and higher, which leads the body to put out more insulin, and we eventually develop insulin resistance, heading on our merry way to becoming diabetic. So we are told, do not eat the white - white bread, white rice, etc; eat the brown, denser, more fibrous, more nutritious version instead - all the while oblivious to these dangerous lectins hidden in the bran we have been consuming.So why is it that our blood sugars are spiking after eating such higher glycemic foods? Is it because they are turning into sugar too quickly? Or is it because of WGA and other lectins interfering with insulin, confusing the body, confusing the cells, keeping the cells from moving glucose in for fuel? Is it a combination of both? Probably this last one, but I'm now thinking it's more heavily weighted to the side of the lectins.In addition, some lectins interfere with neurotransmitters, such as serotonin (and by the way, 95% of all serotonin is made in your gut, not your brain). I usually get quite sleepy after a meal, sometimes it's impossible to stay awake. I usually attributed that to a rise in blood sugar, though that didn't make too much sense when the rises only reached the 140-160 range or when my BS was normal. Since lectins can interfere with neurotransmitters, I wondered if the lectins were the culprits here tooSo to get to my point. :) Sometimes, eating out or fast food seems to be the only option. And no matter how hard you try, you're probably going to take a good hit in the blood sugar department. I know that after eating a bean burger, a salad, and a raspberry ice tea, I could expect to see a spike in blood sugar into the 160's - 180's (and I would take cinnamon to bring it back down). If my ideas about elevated blood sugar and cause of sleepiness after a meal above are right, and if this supplement works as described, then, theoretically, it stands to reason if I take this supplement beforehand, I should be able to eat a hamburger with everything on it, fries, etc, and see my blood sugar stay stable (without cinnamon), and not experience sleepiness.So I ordered this supplement. I received it Sunday 5/21, and started putting it, and my theory, to the test, looking for normal blood sugars which should be between 120-140 for a high at one hour post meal, and less than 120 at two hours post meal.1st evening - I took this supplement just after I started eating: McDondalds - Quater Pounder, everything on it, with a large half cut sweet tea. I took my BS 1 hour post meal - 135. I was shocked. 2 hours post meal it was less than 120. No cinnamon, No sleepiness. Just constant energy.2nd day - lunch (my first meal as I had to be fasting for a lab test): Took the supplement before eating: Burgerville - Tilamook Cheese Burger with everything, Fried Asparagus with garlic aioli sauce, and a large raspberry ice tea. 1.5 hour post meal BS= 128. 2 hours post meal BS = 113. No cinnamon, No Sleepiness, just constant energy.I tried a snack that evening without the Lectin Lock - cinammon raisen bread toasted with coconut oil - and my bs spiked over 140. Tried the same snack the next morning with Lectin Lock and my BS was 105 an hour later. Used Lectin Lock with 2 more meals and my BS' were all nice and low.Today, Wed 5/24, I had the run in with the tofu, but while my BS still spiked to over 160 at one hour with grogginess that lasted most of the day, the 2 hour BS was below 120.So far I've used it with 6 meals and they have all resulted in normal blood sugars except one at 1 hour was in the 160's, but then below 120 at 2 hours - so 5.5 for 6 success rate thus far.Not only does this seem to follow with my idea that it's not the glycemic index or load that is the real issue, but the lectins in the foods we eat disrupting insulin; but also that this supplement is indeed working and working well! Is the energy and lack of sleepiness the result of normal blood sugars? Or did the supplement also successfully block lectins that would affect neurotransmitters leading to the sleepiness I experienced previously? It's hard to say, but I'm leaning towards the lectin explanation as having the greater weight, which seems to bear out with my run in today with the tofu, that even after my bs was down in the 80;s I felt like someone had drugged me most of the day.6 meals with Lectin Lock do seem to demonstrate a favorable repeating pattern. Could this simply be coincidental? It could be. But I really don't think so.Now I don't expect that this supplement is going to block all dangerous lectins - as I saw today with the response to the tofu - but this seems to be a darn good start.